Isaac Fragoso ha enfrentado a 11 oponentes a lo largo de su carrera.
| Player | Team(s) | Games |
|---|---|---|
| Noe Alonzo | 1 | |
| Jeffrion Aubry | 1 | |
| Fernando Benitez | 1 | |
| Luis Bethelmy | 1 | |
| Francisco Cruz | 1 | |
| Leroy Davis | 1 | |
| Isaac Gutierrez | 1 | |
| Elvis Medina | 1 | |
| Mike Mitchell | 1 | |
| Carlos Rivera | 1 | |
| Arim Solares | 1 |